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Is Histamine the reason you are depressed?

Is Histamine the reason you are depressed?Taking antihistamines for your allergies?

Anxious or depressed?

Suffer with migraine headaches?

You may have a histamine imbalance if you have answered yes to these questions.

Histamine is a neurotransmitter or brain chemical derived from an amino acid called histadine. Histamine is well known for its association with allergies, eczema, or hayfever. It acts as an essential neurotransmitter to balance mood. Histamine is involved in the sleep cycle and is required for learning, memory and alertness. Histamine regulates appetite and perception of pain.

Histamine imbalances play a major role in mental health due to its regulation of stress hormones.
High histamine levels are seen in depression, OCD, autism and recurrent migraine headaches.

Signs and symptoms of Histadelia (high Histamine)

  • high libido
  • hyperactivity
  • blank mind episodes
  • chronic depression
  • strong suicidal thoughts
  • low pain tolerance
  • seasonal allergies and frequent colds
  • rapid metabolism
  • profuse sweating
  • frequent stomach aches, pain
  • high energy
  • high inner tension
  • strong will
  • social isolation
  • light sleeper
  • addictive tendencies

Low histamine levels (Histapenia) is associated with mental health issues. Histamine is required for arousal, pain perception and regulates adrenal function. Histapenia patients are likely to suffer depression, poor motivation, self-mutilation and anxiety. Typically, low histamine manifests as depression, poor motivation, anxiety, and more complex mental health conditions like schizophrenia, alcoholism and dementia.

Signs and symptoms of low Histamine (Histapenia)

  • food sensitivity
  • depression
  • grandiosity
  • poor motivation
  • tinnitus
  • low libido
  • panic and anxiety
  • self mutilation and self isolation

Histamine levels is one of many ways to assess methylation. Histadelics are predominantly undermethylators. Dr Carl Pfeiffer is his extensive publications on ADD, and ADHD has shown that restoring methylation with specific natural nutrients can normalize methylation and histamine.

Sexual attraction with histamine

Hormonal dysregulation may contribute to mental health conditions like depression. Research has shown that histamine release is increased by oestrogen. Oestrogens are essential hormones required for regulation of sex, vaginal lubrication, and maintenance of PMS and menopause. A lack of oestrogens brings about a lack of interest in sex, dry vagina, hot flushes, moodiness and irritability.

Oestrogens make you more attractive to the opposite sex, induce pheromones and odors. Histamine induces neurons that stimulate arousal, motivation or vocalisation and libido. The excitatory effect of histamine on arousal is enhanced by oestrogen. In a female oestrogens peak in the productive years in line with their libido. As a male ages, oestrogen production increases particularly during their midlife. This may be the reason why males during their midlife crisis cause more histamine to be released.

Histamine could be why you could be attracted to the opposite sex. [Ref: In “Histamine-Induced Excitatory Responses in Mouse Ventromedial Hypothalamic Neurons: Ionic Mechanisms and Estrogenic Regulation” Journal of Neurophysiology Published 1 December 2007 Vol. 98no. 3143-3152]

Testosterone in men tends to convert to estrogen as men age leading to andropausal symptoms like pot belly, receding hairline and the old “grumpy man’s syndrome”. Estrogen and histamine stimulation can be one mechanism by which men may seek extramarital sexual relationships – we colloquialise this a mid-life crisis!!

In females, histamine is produced by the mast cells and endothelial cells in uterus and ovary. As Histamine increases oestradiol production thereby causing a decline in progesterone. This leads to cyclical headaches and painful periods. The painful uterine contractions associated with dysmenorrhea are caused by an increased production of inflammatory prostaglandins which is stimulated by oestrogens and inhibited by progesterone. This is why progesterone or progesterogenic herbs are useful for PMS. Histamine can therefore intensify PMS and pain via an increase in estrogen production.

Histamine antagonists like cimetidine can contribute to low libido and erectile dysfunction by reducing the uptake of testosterone. Injections of histamine in men with impotence has been shown to improve erections.

Sexual offenders and Histadelia

Could there be a correlation between high histamine (Histadelia) with sexual offenders or rapists?

Histadelia, is a disorder of too much histamine and seems to be prominent in males. These sexual offenders will experience phobias or no phobias at all, chronic depression, hyperactivity, agitated, compulsions, obsessions, and have a lean build, rapid metabolism, and will sweat profusely. They will also have a high imagination, have lots of saliva, low tolerance to pain, very strong sexual desires and have addictive personalities.

Testing for Histamine

Histamine can be tested as a functional pathology test in a blood sample. It is appropriate to delve deeper into the metabolic blocks associated with histamine imbalance by identifying in-depth testing for mental health, testing for female hormones, testing for male hormones, testing for mental health.

Regulating Histamine requires detailed assessment of Histamine with other excitatory and inhibitory neurotransmitters and correcting them with appropriate natural inhibitors or inducers. To ascertain the relevance of Histamine within the sexual offender, it is important to identify upstream regulators.

If you would like further information or assistance on the topic of histamines, please contact Vanita Dahia.

by Vanita Dahia